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KMID : 0617219960070010121
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Duksung Bulletin Phamaceutical Sciences
1996 Volume.7 No. 1 p.121 ~ p.151
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Synthesis of 1,2-diazine derivatives
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Abstract
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Although the first pyridazine was obtained in 1886, this heterocycle was not thoroughly investigated as pyrimidines and pyrazines especially in the field of drug development because pyridazines do not occur as natural products. Recently medicinal chemists have an growing interest in the pyridazine derivatives, since many pyridazine derivatives were found to possess various potential therapeutic activities. Among the biological activities antihypertensive and cardiotonic activities are most popular. In this paper syntheses of all pyridazine derivatives which are used as drugs or under development as antihypertensive and cardiotonic therapeutics were reviewed since 1976 and the relationship of structure-activities was discussed.
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KEYWORD
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